Statistical analysis of dendritic spine distributions in rat hippocampal cultures


Dendritic spines serve as key computational structures in brain plasticity. Much remains to be learned about their spatial and temporal distribution among neurons. Our aim in this study was to perform exploratory analyses based on the population distributions of dendritic spines with regard to their morphological characteristics and period of growth in dissociated hippocampal neurons. We fit a log-linear model to the contingency table of spine features such as spine type and distance from the soma to first determine which features were important in modeling the spines, as well as the relationships between such features. A multinomial logistic regression was then used to predict the spine types using the features suggested by the log-linear model, along with neighboring spine information. Finally, an important variant of Ripley’s K-function applicable to linear networks was used to study the spatial distribution of spines along dendrites.

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A. Jammalamadaka, S. Banerjee, B.S. Manjunath and K. Kosik,
BMC Bioinformatics, vol. 14, no. 287, Oct. 2013.
Node ID: 610 , DB ID: 420 , Lab: VRL , Target: Proceedings
Subject: [Bio-Image Informatics] « Look up more